PerlRequire isn't standard apache, it's a mod_perl directive.
nginx does have a perl module you can enable (http://nginx.org/en/docs/http/ngx_http_perl_module.html)
HOWEVER
your application may be incompatible with nginx.
mod_perl is used in a few situations to let developers:
1. run perl scripts in Apache
2. build an application into Apache's with Perl (ie, building against config/runtime hooks in Apache itself)
If your perl does 1, it will probably run.
If your perl does 2, it would most likely need a heavy rewrite
